Product information

Drug Name

Trental (Pentoxifylline)
Drug Uses

Trental is used for treating intermittent claudication (pain, cramping, numbness, or weakness in the foot, hip, thigh, or buttocks) in certain patients. It may also be used for other conditions as determined by your doctor.
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Use Trental as directed by your doctor.
Take Trental by mouth with food or milk.
Swallow whole. Do not break, crush, or chew before swallowing.
Ask your health care provider any questions you may have about how to use Trental.

Drug Class and Mechanism

Trental is a xanthine derivative blood flow enhancer. It works by thinning the blood and improving red blood cell flexibility, causing the blood to flow more freely through the veins.
Missed Dose

If you miss a dose of Trental and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
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Store Trental at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Trental out of the reach of children and away from pets.

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Product information

Drug Name

Trandate (Labetalol)
Drug Uses

This medication is used to treat severe high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
How to use

Follow the directions for using this medicine provided by your doctor. Take this medicine with food or milk.
Drug Class and Mechanism

Trandate is a drug that is used for treating high blood pressure. It is related to carvedilol (Coreg). Nerves that are part of the adrenergic nervous system travel to most arteries where they release an adrenergic chemical norepinephrine. The norepinephrine attaches to receptors on the muscles of the arteries and causes the muscles to contract, narrowing the arteries, and increasing the blood pressure. Trandate blocks receptors of the adrenergic nervous system. When trandate attaches to and blocks the receptors, the arterial muscles relax, and the arteries expand, resulting in a fall in blood pressure. The FDA first approved Trandate in 1997.
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If the dose is interrupted, contact the doctor immediately to re-establish dosing.
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Store the vials at room temperature between 36 and 86 degrees F (2 to 30 degrees C) and away from light. Do not freeze. After dilution in the correct IV fluids, this product is stable for 24 hours refrigerated or at room temperature. Discard any unused liquid.

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Toprol XL (Metoprolol)
Drug Uses

Toprol XL is used for treating high blood pressure, alone or with other medicines; long-term treatment of chest pain; and reducing the risk of death because of heart problems in patients who have had a heart attack. It may also be used for other conditions as determined by your doctor.
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Seizures may be classified as either partial if they involve only a small portion of the brain or generalized if they involve more of the brain. Topamax is used in combination with other anti-seizure drugs among adults and children aged 2-16 years with partial seizures or generalized tonic-clonic seizures (in which there is prolonged contraction of the muscles of the body that causes rigidity as well as jerking motions). Topamax sprinkle capsules are approved for treatment without other drugs in patients 10 years of age and older. Topamax also is used in patients two years of age and older with seizures associated with the Lennox-Gastaut Syndrome, a severe form of epilepsy which accounts for up to 10 percent of all cases of childhood epilepsy. Children with Lennox-Gastaut Syndrome experience delays in their development and up to dozens of different, mixed types of seizures a day. The most common types of seizures in this syndrome are tonic (stiffening of the body, with the eyes rolling upwards, dilation of the pupils and shallow, irregular breathing), atonic (brief loss of muscle tone and consciousness, causing abrupt falls), myoclonic (sudden muscle jerks), and absence (staring spells).
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Topamax is an oral drug that is used to prevent the seizures of epilepsy. (It is an anti-epileptic or anti-seizure drug). It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Topamax also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although topamax's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, topamax may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that topamax may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire.
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If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
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Drug Name

Topamax (Topiramate)
Drug Uses

Seizures may be classified as either partial if they involve only a small portion of the brain or generalized if they involve more of the brain. Topamax is used in combination with other anti-seizure drugs among adults and children aged 2-16 years with partial seizures or generalized tonic-clonic seizures (in which there is prolonged contraction of the muscles of the body that causes rigidity as well as jerking motions). Topamax sprinkle capsules are approved for treatment without other drugs in patients 10 years of age and older. Topamax also is used in patients two years of age and older with seizures associated with the Lennox-Gastaut Syndrome, a severe form of epilepsy which accounts for up to 10 percent of all cases of childhood epilepsy. Children with Lennox-Gastaut Syndrome experience delays in their development and up to dozens of different, mixed types of seizures a day. The most common types of seizures in this syndrome are tonic (stiffening of the body, with the eyes rolling upwards, dilation of the pupils and shallow, irregular breathing), atonic (brief loss of muscle tone and consciousness, causing abrupt falls), myoclonic (sudden muscle jerks), and absence (staring spells).
How to use

Most commonly, topamax is started in low doses, 25 or 50 mg per day, and then increased slowly, under a doctor's orders, by 25 to 50 mg per week until an effective daily dose is reached. This slow approach to treatment reduces side effects. In children, the starting dose is up to 25 mg (1 to 3 mg/kg/day), taken nightly for the first week. The dose is then increased at 1 or 2 week intervals by 1 to 3 mg/kg/day. Although the usual adult dose is 200 mg twice daily, some adult patients may begin to see a clinical response at 200 mg per day. Some patients need doses higher than 200 mg daily. In children, the usual dose is 2.5 to 4.5 mg/kg twice daily. Patients should maintain an adequate fluid intake in order to minimize the risk of kidney stones.
Drug Class and Mechanism

Topamax is an oral drug that is used to prevent the seizures of epilepsy. (It is an anti-epileptic or anti-seizure drug). It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Topamax also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although topamax's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, topamax may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that topamax may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire.
Missed Dose

If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Storage

Topamax tablets should be stored at room temperature, 59-86 degrees F (15-30 degrees C). Sprinkle capsules should be stored at or below 77 degrees F (25 degrees C).

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